Genetics of Dupuytren's disease

It was first recognised in 1833 that there was an inherited predisposition to Dupuytren’s Disease, before DNA and genes were discovered (1). Since then, hand surgeons have continued to be fascinated by the nature and extent of this predisposition. As epidemiological methodology and molecular genetic techniques have developed, our understanding has advanced, such that the design of novel therapeutic interventions based on this knowledge is becoming a realistic possibility. In this section, we begin by briefly reviewing important principles and concepts of genetic inheritance. We then assess the evidence for a genetic predisposition to Dupuytren’s Disease. Next we consider the molecular genetic studies that have helped define the magnitude and nature of that genetic predisposition. Finally, we consider potential future developments in this fast developing field. Genetics of Dupuytren's disease The basics of genetic inheritance